Epidermal growth factor receptor (EGFR) has been recognized as contributing to head and neck squamous cell carcinoma (HNSCC) development and progression, but the prognostic value of many specific EGFR molecular characteristics have not been evaluated alone or in combination. This study was carried out by THANC to define the relationship between EGFR gene amplification, gene expression, and protein and phosphoprotein levels in prospectively collected tumor tissues from a cohort of HNSCC patients treated with surgery with curative intent.
Sarah Wheeler, Doris R. Siwak, Raymond Chai, Courtney LaValle, Raja R. Seethala, Lin Wang, Kathleen Cieply, Carol Sherer, Corwin Joy, Gordon B. Mills, Athanassios Argiris, Jill M. Siegfried, Jennifer R. Grandis and Ann Marie Egloff
Clinical Cancer Research, April 2012