Metastatic squamous cell carcinoma of unknown primary (MUP) continues to present a dilemma in the planning of therapeutic strategy. Radiation therapy constitutes an important component for the management of MUP, however, targeted versus comprehensive radiation remains a point of contention in the literature. THANC explores the long-term outcomes of patients with MUP treated with conservative mucosal-sparing radiation therapy targeted only to the oropharynx and bilateral neck.
Waleed F. Mourad, Kenneth S. Hu, Daniel Shasha, Catherine Concert, Dan Ishihara, Wilson Lin, Rania A. Shourbaji, Magdalena Ryniak, Mauricio E. Gamez, John N. Lukens, Zujun Li, Bruce E. Culliney, Azita S. Khorsandi, Theresa Tran, Adam Jacobson, Spiros Manolidis, Stimson Schantz, Mark Urken, Mark S. Persky and Louis B. Harrison
Anticancer Research, January 2014