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Research

Thyroid Head & Neck Research Center (THNRC)

In 2009, we opened the functional outcomes clinical research center at Mount Sinai Beth Israel, which is the sole US site of the international Head and Neck Research Network (HNRN). This network of research centers was developed in 2008 to create global outreach with the intent of performing critical assessments of patients before and after treatment for head and neck and thyroid cancers. The current centers located in Edmonton, Canada and Turku, Finland conduct research in a wide range of areas and evaluates outcomes following head and neck cancer treatment. Our laboratory studies the impact of various treatments including surgery, radiation, chemotherapy, and prosthetic rehabilitation on patient function and quality of life. The research center assesses outcomes with a fast track to achieve statistical significance, to guide the future of patient care in head and neck and thyroid cancer.

Year in Review // 2015

Comparison of Protocols (2013-2014)

A  Prospective Study Examining the Effects of ORN Surgery on Functioning

  • 2014 » 14
  • 2013 » 9

B  Clinical Criteria for Percutaneous Endoscopic Gastrostomy (PEG) Tube Placement in Chemoradiotherapy Patients

C  Voice in Total Laryngectomy

D  Outcomes Study – Effects of Chemoradiotherapy on Economic Outcomes

E  Outcomes Study – Effects of Tongue Cancer Surgery on Functional Outcomes

  • 2014 » 14
  • 2013 » 9
B

Clinical Criteria for Percutaneous Endoscopic Gastrostomy (PEG) Tube Placement in Chemoradiotherapy Patients

  • 2014 » 117
  • 2013 » 104
C

Voice in Total Laryngectomy

  • 2014 » 14
  • 2013 » 13
D

Outcomes Study – Effects of Chemoradiotherapy on Economic Outcomes

  • 2014 » 43
  • 2013 » 33
E

Outcomes Study – Effects of Tongue Cancer Surgery on Functional Outcomes

  • 2014 » 40
  • 2013 » 31

Functional Outcomes Studies

  • 2015 » 549
  • 2014 » 464

Instrumental Swallow Evaluations

  • 2015 » 1111
  • 2014 » 938

Functional Assessments

  • 2015 » 1554
  • 2014 » 1318

Most Recent Published Articles

Osteoradionecrosis of the subaxial cervical spine following treatment for head and neck carcinomas.

The British Journal of Radiology, January 2015

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Database and registry research in thyroid cancer: striving for a new and improved national thyroid cancer database.

Thyroid, February 2015

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Size distribution of metastatic lymph nodes with extranodal extension in patients with papillary thyroid cancer: a pilot study.

Thyroid, February 2015

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Intraoral sebaceous carcinoma metastatic to the lung and subcutis: Case report and discussion of the literature.

Head & Neck, April 2015

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Studies and Papers Currently In Progress

C-Arm Videofluoroscopic Swallow Study in the Supine Vs. Upright Position

Primary Investigator: Cathy Lazarus, PhD

This study intends to determine the differences between a normal swallow while upright vs. that while in a supine position utilizing videofluoroscopy (x-ray) in healthy individuals. We anticipate that this pilot study will provide support for using MRI imaging of swallowing with different patient populations, including dysphagic head and neck cancer patients.

Comparing Lingual Exercises & Standard Care for Dysphagia Treatment

Primary Investigator: Cathy Lazarus, PhD

This study observes the effects of an 8-week tongue strengthening exercise program on swallowing in dysphagic patients. A similar control group will undergo standard treatment. Both groups will undergo baseline and post-treatment tongue strength assessment and videofluoroscopic swallow assessment to define changes in tongue strength and swallowing with treatment.

Alleviating Pain with Self-Hypnosis

Primary Investigator: Mark Urken, MD

This pilot study titled, Integrative Therapy to Palliate Oral Cancer Pain: A Feasibility Study examines the effects of self-hypnosis on pain prior to surgery for oral cancer. Outcomes include pain level, quality of life and performance status. Changes to the blood bio-markers with reduction in pain are also assessed in this study.

Chest Flap Reconstruction

Primary Investigator: Cathy Lazarus, PhD

This study examines the impact of neck dissection with and without chest flap reconstruction on arm and shoulder range of motion and strength, as well as the patient’s quality of life.

OVERALL
PARTICIPATION

 16.8%

Voice, speech, tongue function, swallowing and quality of life assessments have been conducted since the Thyroid Head and Neck Research Center’s inception in November 2009. Researchers have seen both pre- and post-treatment patients and individuals who have undergone chemoradiotherapy and/or surgery.

Total No. of Participants

  • 2015 » 878
  • 2014 » 780

More Research Articles

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